Another study reported that GH could promote proliferation, while pegvisomant (a GH antagonist) reduced apoptosis, regulated the expression of cancer-related genes in PTEN-P2, PTEN-CaP2, PTEN-P8, and PTEN-CaP8 cells [106], and increased LNCaP cells migration and invasion capacity [107] (Fig. 4). Here, GH1 is linked to cancer.