AVPR1A and neoplasm: Moreover, the knocking-out of this receptor resulted in decreased proliferation in castration resistant prostate cancer cell lines 22Rv1, CWR-R1, C4-2B, and LNCaP-abl, while overexpression of AVPR1A in LNCaP cells resulted in increased proliferation (in absence of androgen) and increased subcutaneous xenograft tumor growth in castrated mice.