This result indicated that paracrine interactions between RL95-2 and JAR cells were healthy under the influence of 3D culture induced by BC.However, considering that there was a difference only in N-cadherin and Vimentin immunoreactivity in RL95-2/JAR cells compared to JAR cells and no difference in other mesenchymal cell markers, it was concluded that BC partially mimics the 3D endometrium-like culture system. The gene discussed is CDH2; the disease is breast cancer.