These scaffolds are frequently used in cancer cell metastasis and invasion studies, A three-dimensional endometrium-like culture system was established to quantitatively investigate the role of E-cadherin, N-cadherin, Vimentin, α-smooth muscle actin and Syndecan-1 proteins in the type 1 epithelial mesenchymal transition mechanism observed during the invasion step of the implantation process. The gene discussed is CDH2; the disease is cancer.