MAPT and tauopathy: Although cryo-EM highlights distinct tau filament core conformations in different tauopathies (31, 32, 33, 34, 35), growing evidence points to common conformational changes of tau into nonfilamentous species associated with toxicity (6, 11, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45).