In this specific case, pathological anatomy initially suggested a liposarcoma lesion; however, immunohistochemistry testing revealed a negative Desmin result, effectively eliminating the liposarcoma diagnosis and underscoring the nuanced complexity of accurate tumor classification.<h4>Conclusion</h4>This case report highlights the diagnostic difficulty in identifying divergent differentiation in sarcomas, using MPNST and liposarcoma as examples. Here, DES is linked to sarcoma.