CD274 and neoplasm: High GPx4 expression was significantly correlated with advanced N stage (P = 0.038), M stage (P = 0.023), and TNM stage (P = 0.023), but not with other factors such as age, gender, tumor location, Lauren type, Borrmann type, differentiated degree, T stage, HER2 status, or PD-L1 status (Supplementary Table 3).