To study this interaction, we generated neuroblastoma cell lines with genetic depletion of MDK (SK-N-AS-shMDK and SH-SY5Y-shMDK) or MIF (SK-N-BE2C-shMIF and Kelly-shMIF) using shRNA-mediated silencing (Fig. 3c,d, Supplementary Fig. 5a–c). This evidence concerns the gene MIF and neuroblastoma.