STING1 and Alzheimer disease: To determine the cell population responsible for cGAS elevation in AD, we treated 5xFAD mice with CSF1R inhibitor PLX5622, a compound known to selectively deplete microglia.[27] In line with the induction of cGAS signaling observed in human AD, both cGAS and STING protein levels were significantly induced in 5xFAD mice compared to age‐matched wild‐type controls (Figure 1c).