To explore the potential impact of cGAS up‐regulation in the process of AD development, we generated a tamoxifen‐inducible, microglia‐specific cGAS knockout mouse line (mKO) by crossing Cx3cr1‐CreERT2 mice with cGAS flox/flox mice (Loxp) (Figure S2a, Supporting Information). Here, CX3CR1 is linked to Alzheimer disease.