Pathways that were consistently impacted in both human and mouse AD, recovered to normal levels in the 5xFAD‐mKO group, encompassing bone morphogenetic protein (BMP) signaling, fibroblast growth factor (FGF) signaling, pleiotrophin (PTN) signaling, neuregulin (NRG) signaling, and growth arrest‐specific (GAS) signaling (Figure S6c,d, Supporting Information). This evidence concerns the gene PTN and Alzheimer disease.