GABRA2 and psychotic disorder: Goetjen et al. explored the methylation at the GABRA2 promoter in the context of AUD, revealing that methylation is associated with decreased GABRA2 gene expression, which extends to the GABRB1 gene, indicating a potential epigenetic mechanism in AUD [5] Similarly, Guidotti et al. investigated the DNA methylation/demethylation network in psychotic patients with a history of alcohol abuse, finding alterations in DNA-methyltransferase-1 (DNMT1) and other related enzymes, suggesting a complex interplay between alcohol abuse and epigenetic regulation in psychotic disorders [6].