Based on previous studies that highlightedthe use of α-mannose-α-1,2-mannose (Manα1,2Man ordiMan) enhanced the affinity for DC-SIGN by 3−4 times in comparisonwith the monosaccharide α-mannose (Man),26,27 these glycoSiNPs were decorated with both Man and Manα1,2Manor trivalent dendrons of these carbohydrates to compare their capacityto block DC-SIGN and therefore to inhibit pathogen infection. This evidence concerns the gene CD209 and infection.