One case (AML#2) harbored a nonsense mutations in the cytoplasmatic domain [p.(Tyr787*)] of CSF3R together with NPM1-nonABD and DNMT3A mutations; the other (AML#9) had a missense variant (VUS) in the extracellular domain [p.(Gly539Asp)] of CSF3R gene, NPM1-nonABD and FLT3-TKD mutations. Here, NPM1 is linked to acute myeloid leukemia.