CSF3R and acute myeloid leukemia: In AML patients we found 14 CSF3R variants; among them, 7 (50.0%) were localized in the extracellular domain (one nonsense and 6 missense), 3 mutations (21.4%) in the transmembrane proximal domain (two missense T618I and one delins), 3 (21.4%) in cytoplasmatic tail (W787* nonsense variant, S783Qfs frameshift variant and a missense variant) and 1 (7.1%) is a splicing variant (Fig. 2C).