IL6 and rheumatoid arthritis: It can regulate the production of immunoglobulin by mediatingthe differentiation of activated B cells into immunoglobulin-producingplasma cells.1 Yet, the dysregulation ofIL-6 would also be harmful, such as rheumatoid arthritis, one kindof chronic inflammation in which excessive IL-6 was detected in synovialfluids from the joints of patients.2 Apartfrom immune responses, IL-6 is reported to have an influence on energycontrol, for example, lipids, glucose, and protein metabolism.3