CTLA4 and non-small cell lung carcinoma: For instance, the weighted means of HWG of trajectories 1 and 2 in NSCLC which are associated with high activities of cytotoxic T cells, predicted better responses to anti-PD-130 and anti-CTLA-4 (Cho et al., 2020; Liu et al., 2018), as well as their combination therapies (Auslander et al., 2018) (AUC∈{0.813,0.964}, P<0.1, Figure 5—figure supplement 3).