Antiphospholipid and anti-MDA5 (melanoma differentiation-associated gene 5) were detected in COVID-19 patients, and higher titers of these autoantibodies were associated with disease severity and unfavorable outcomes (intensive care, much longer disease course at discharge, and higher incidences of respiratory failure, shock, and other organ dysfunction) (12,13). Here, IFIH1 is linked to COVID-19.