RICTOR and hepatocellular carcinoma: Overexpression of RICTOR is positively associated with tumor progression and poor survival in colorectal cancer, hepatocellular carcinoma (HCC), endometrial carcinoma, pituitary adenoma, and pancreatic ductal adenocarcinoma.47 Using next-generation sequencing, it was shown that RICTOR up-regulation strengthens mTORC2 activity, promoting cell growth and motility.