The mTOR-independent ILK/RICTOR complex was detected in several cancer cell lines and is involved in Transforming Growth Factor (TGF) beta-1-mediated EMT.48 RICTOR promotes tumor progression regulating the tumoral microenvironment by increasing cell proliferation and survival, decreasing apoptosis in cancer cells, facilitating angiogenesis, and remodeling the stroma. The gene discussed is RICTOR; the disease is cancer.