Furthermore, TIMER2 showed that HNSCC patients with high levels of CD4+ and CD8+ T cell infiltration had a better prognosis at high ZC3H12D expression levels, and high B cell infiltration levels corresponded to a better prognosis at consistent ZC3H12D expression levels (Supplementary Figure S3A-C). This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.