According to the fold enrichment score, the top 20 pathways were Amyotrophic lateral sclerosis (ALS), Long-term potentiation, Thyroid cancer, Non-small cell lung cancer, B cell receptor signaling pathway, Melanoma, Long-term depression, VEGF signaling pathway, Colorectal cancer, Cysteine and methionine metabolism, Renal cell carcinoma, Amphetamine addiction, Bladder cancer, Glucagon signaling pathway, Prolactin signaling pathway, Dopaminergic synapse, Renin secretion, and Hepatitis B, Pancreatic cancer, Glioma. Here, REN is linked to central nervous system cancer.