High levels of GDF15 activate this receptor, thus causing anorexia and cachexia.[12, 13] The apparent discrepancy between the widespread expression and pleiotropic actions of GDF15,[14] and the restricted localization of GRAL in NTS/AP, lead to hypothesize a more extensive receptor distribution, maybe at low but biologically sufficient levels. This evidence concerns the gene GDF15 and Anorexia.