Although a recent study has shown that the administration of native GDF15 is associated with nausea, vomiting and visceral malaise,[49] and although studies have also shown that neutralizing GDF15 can ameliorate cancer cachexia,[51] most evidence has been gathered from animal studies,[49, 50] and evidence in humans ‐ either under physiological or pathological conditions ‐ seems promising, yet limited.[52]. The gene discussed is GDF15; the disease is cancer.