Based on the finding that WNT5A/PCP/JNK is upregulated, we selected WNT5A, together with its cognate co-receptor ROR2, as a crucial signalling regulator for JNK signalling in AD for the subsequent analysis, as the ROR genes show redundancy in synaptogenesis (Ramos et al., 2021). Here, ROR2 is linked to Alzheimer disease.