At the molecular level, the accumulation of amyloid-β (Aβ) peptides and tau protein tangles in neurons are some hallmark characteristics of AD, contributing significantly to the disease's pathogenesis (Hardy and Selkoe, 2002; Karran et al., 2011; Pluta et al., 2021; Tolar et al., 2020; Vogel et al., 2020; Wei et al., 2021). This evidence concerns the gene MAPT and Alzheimer disease.