Interestingly, recent reports indicate that JNK signalling is upregulated in AD, has been linked to Aβ signalling (Shoji et al., 2000; Solas et al., 2023), and that JNK inhibitors have a neuroprotective function and increase neuronal survival (Harper and LoGrasso, 2001). The gene discussed is MAPK8; the disease is Alzheimer disease.