Then top-ranked GBM-causing 16 oncodriver genes (DLX6, MTCH2, SSC5D, ANKRD36, VWF, FLG, WDR89, GOLGA6L2, GNAQ, MUC17, OR10G7, IRS2, GXYLT1, TMEM163, MUC16 and KMT2C) were detected from the somatic mutated gene-set (Fig. 4A) by using the OncodriveClust algorithm. This evidence concerns the gene FLG and glioblastoma.