Multiple distinct classes of these drugs, including angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, and beta-blockers, have been implicated in both disease induction and exacerbation in both PV (20–22, 26, 58) as well as other cutaneous diseases, as illustrated by the well-documented association of beta-blockers with psoriasis (59–61). This evidence concerns the gene ACE and psoriasis.