In this study, by performing a clustering analysis based on transcriptional expression of ACRG in the pan-cancer cohort, we found that compared to other tumor types, which tend to cluster together due to similarity in ACRG transcriptional expression patterns, the ACRG expression characteristics of glioma patients have strong cancer species specificity; more than 90% of patients in the AC-V subtype are diagnosed with glioma, while each of the other four subtypes contains over 15 tumor types. This evidence concerns the gene COMMD6 and central nervous system cancer.