Consequently, pro-inflammatory IL-17 signaling culminates in the transcription of target genes vital for inflammation and defense against infections, encompassing proteins like TNF, IL-6, IL-1β, IL-8, CXCL1, CXCL8, CXCL10, ICAM1, GM-CSF, and a plethora of chemokines including CXCL1, CXCL2, CXCL5, CXCL8, CXCL10, CCL2, and CCL20, as well as matrix metalloproteinases (MMPs) such as MMP1, MMP2, MMP3, MMP9, and MMP13 (67). Here, CXCL8 is linked to infection.