CXCL1 and infection: Consequently, pro-inflammatory IL-17 signaling culminates in the transcription of target genes vital for inflammation and defense against infections, encompassing proteins like TNF, IL-6, IL-1β, IL-8, CXCL1, CXCL8, CXCL10, ICAM1, GM-CSF, and a plethora of chemokines including CXCL1, CXCL2, CXCL5, CXCL8, CXCL10, CCL2, and CCL20, as well as matrix metalloproteinases (MMPs) such as MMP1, MMP2, MMP3, MMP9, and MMP13 (67).