Clinical Pancreatic Tumor samples; Genetically Engineered Mice:Il17ra-/-Il17rc-/-Il17rafl/fl; Anti-IL-17 treatment in the orthotopic pancreatic tumor model; Murine PDAC KPC (KPCIl17ra+/+) (LSL-KrasG12D/+; LSL-Trp53R172H/+;Pdx1-Cre) cells. The gene discussed is PDX1; the disease is pancreatic neoplasm.