Furthermore, in intestinal epithelial cells (IECs), microbiota in intestinal tumors up-regulates IL-17C through Toll-like receptor (TLR) -MyD88-dependent signaling, and microbiota-driven IL-17C induces Bcl-2 and Bcl-xL expression in IECs in an autocrine manner. This evidence concerns the gene IL17C and intestinal neoplasm.