Recent studies have identified mutations in several genes, including SCN1A, SCN2A, SCN1B, STX1B, SLC2A1, GABRG2, CHD2, SYNGAP1, KIAA2022, NEXMIF, and SLC6A1, that can contribute to the phenotype of Doose syndrome (13–15). Here, STX1B is linked to epilepsy with myoclonic atonic seizures.