PKM and gastric cancer: Certain miRNAs like miR-320 (54) and miR-124 (55) regulate AEG by targeting the Krüppel-like factor (KLF)/HIF-1α pathway and the glycolytic enzyme PKM2, respectively.A study by Hanyu Zhang (56) et al: miR-200a, miR-559, and miR-1236 were negatively associated with CD86, CD81, and CD160, respectively, in almost all types of gastrointestinal cancers, which were further verified in the in vitro studies by transfecting microRNA mimics in gastric cancer, colon cancer, pancreatic, and esophageal cell lines.