KDR and gastric cancer: Lastly, Licoflavone A, a natural flavonoid from Glycyrrhiza, has been demonstrated to inhibit gastric cancer proliferation, induce apoptosis, and reduce migration, invasion, and epithelial-mesenchymal transition by targeting VEGFR-2 and disrupting the PI3K/AKT and MEK/ERK pathways in both in vitro and in vivo settings (113).