The clinical presentation of patients with ALK+ LBCL is similar to that of DLBCL, and includes painless lymph node enlargement on onset, rapid progression, systemic lymph node involvement, and extranodal involvement, and involvement of soft tissues, nasopharynx, tonsils, thoracic wall, mediastinum, pulmonary hilum, liver, and spleen. This evidence concerns the gene ALK and diffuse large B-cell lymphoma.