BCL2 and diffuse large B-cell lymphoma: In addition to BCL-2 translocation and amplification, double-hit lymphomas,which are a rare and aggressive subtype of DLBCL are characterized by MYC oncogene translocation with either the rearrangement of BCL2 or BCL6. The enhanced expression of BCL-2 is also attributed to other processes, including phosphorylation, promoter hypermutation, and hypomethylation (26).