When the tumor cells are deficient in nutrients, the intracellular energy is insufficient, ATP decreases, and AMPK production increases, resulting in the activation of AMPK and the inhibition of mTOR, thus inducing the expression and activation of Caspase-3, of which activation is considered to be the last and irreversible step in the process of apoptosis (34), leading to apoptosis and proliferation inhibition of tumor cells (31, 35). This evidence concerns the gene CASP3 and neoplasm.