Based on the keyword clustering results (Figure 10; Supplementary Table 10), the largest cluster is “Porphyromonas gingivalis (#0),” which includes keywords such as “Porphyromonas gingivalis,” “coronary heart disease,” “C-reactive protein,” “bone mineral density,” and “atherosclerosis.” This cluster centers on Porphyromonas gingivalis and covers several keywords related to systemic diseases, reflecting the potential association between PD and chronic systemic conditions, particularly coronary heart disease, atherosclerosis, and osteoporosis. This evidence concerns the gene CRP and osteoporosis.