INSR and lung carcinoma: ALK, a member of the insulin receptor superfamily of receptor tyrosine kinases, is composed of 29 exons, with exons 20–29 encoding the tyrosine kinase domain (Della Corte et al., 2018) ALK fusions are primarily found in lung cancer, where they occur with a prevalence of approximately 5% (Jazieh et al., 2021).