In the CRIC study (CKD stage 2-4), diastolic function was impaired in 71% of patients [27], while another study found that patients with CKD have a high incidence of structural cardiac abnormalities and diastolic dysfunction [28]. A possible underlying mechanism may be the excessive activation of the renin-angiotensin-aldosterone system, which is known to be a determinant of the onset of profibrotic factors. The gene discussed is REN; the disease is chronic kidney disease.