PE: Pulmonary embolism; PGM: Prothrombin gene mutation; p value <0.05: statistical significance; MI: myocardial infarction; ARDS: acute respiratory distress syndrome; HLD: hyperlipidemia; PVD: peripheral vascular disease; CHF: congestive heart failure; CAD: coronary artery disease; Afib: atrial fibrillation, HTN: hypertension; CVA: cerebrovascular accidents; COPD: chronic obstructive pulmonary disease; ESRD: end stage renal disease; AKI-HD: Acute kidney injury requiring hemodialysis; MV: mechanical ventilation. The gene discussed is F2; the disease is leukodystrophy.