However, 2 loci have been consistently strongly linked to advanced AMD in genome-wide association studies: Complement factor H (CFH) gene at the 1q31 susceptibility locus, where the C allele of CFH Y402H is recognized as a risk factor for AMD, and the 10q26 ARMS2/HTRA1.10 The gene discussed is HTRA1; the disease is age-related macular degeneration.