NFKB1 and chronic kidney disease: To further examine the role of the NF-κB axis in CKD development and how SSKE can improve CKD by regulating the NF-κB axis, we used a small-animal in vivo imaging device to monitor the fluorescence intensity of NF-κB-RE-Luc BALB/c mice in vivo and in vitro kidney tissue in real time.