This result is consistent with previous reports of cancer cellstreated with low doses of etoposide (0.5 μM), inducing apoptosis without alteringcleaved caspase-3, -9, or -8 levels [50].Etoposide can cause either caspase-dependent or -independent apoptotic cell deathdepending on the dose, with caspase-independent apoptosis occurring at low doses[50, 51]. The gene discussed is CASP3; the disease is cancer.