ALOX15 and chronic rhinosinusitis with nasal polyps: Conclusively, an ALOX15 + macrophage subset driving M2 polarization was recently described also in EoE, (123) similarly to CRSwNP, in which IL-4/IL-13/ALOX15 M2 macrophages play a pivotal role (124), thus supporting the aforementioned role of macrophages in T2 inflammatory diseases.