However, an elegant study in mice highlighted the importance of TNF/TNFR signaling in murine arthritis and showcased that synovial fibroblast survival and inflammatory capacity was orchestrated by the p55TNFR–IKK2–Ripk3 axis, suggesting Ikk2 targeting as a potential therapeutic target alongside TNF blockade (128). This evidence concerns the gene TNF and arthritic joint disease.