While HPV-negative tumors are typically more densely innervated, partly due to TP53 mutations, which may contribute to their more aggressive nature and increased pain, HPV-positive tumors, although less densely innervated, promote tumor growth through mechanisms such as CCND1 amplification and the release of exosomal oncogenes like E6 and E7 (21, 31, 123, 124, 126, 275). The gene discussed is TP53; the disease is neoplasm.