EGF and focal segmental glomerulosclerosis: This mirrors findings in studies on focal segmental glomerulonephritis (FSGS), which upregulated the focal adhesion pathway, with key genes like fibronectin 1 (FN1) and protein phosphatase 1 (PP1) being upregulated, whereas EGF and insulin-like growth factor 1 (IGF1) were downregulated, stabilizing the cellular structure via enhanced adhesion to the glomerular basement membrane (28).