Certain pharmacological agents, such as resveratrol (RES), an ATPase inhibitor, can directly affect mitochondrial function by suppressing the aerobic respiratory chain in tumor cells, consequently hindering ATP production for metabolic therapy (Wan et al., 2020; Wang et al., 2023a; Zhang et al., 2023; Tang et al., 2024). The gene discussed is DNAH8; the disease is neoplasm.