However, studies also indicate that adropin-mediated immune and inflammatory regulation is involved in the pathogenesis of several metabolic and non-metabolic diseases, such as atherosclerosis (36), diabetes (58), NAFLD (59), gastric ulcers (60), and inflammatory bowel disease (18) (Table 1, Figure 3). The gene discussed is ENHO; the disease is metabolic dysfunction-associated steatotic liver disease.