ENHO and fatty liver disease: Furthermore, adropin knockout (AdrKO) exacerbated hepatic steatosis, inflammation, and fibrosis, while adropin treatment alleviated these conditions by promoting the expression of Gclc, Gclm, and Gpx1, as well as increasing glutathione (GSH) levels in an Nrf2-dependent manner, thereby preventing NASH progression in mice (10).