CSF3 and chronic kidney disease: In rats with adenine-induced chronic renal failure, adropin treatment was shown to reduce the expression of several pro-inflammatory cytokines, including G-CSF (granulocyte colony-stimulating factor), IFN-γ, IL-4, IL-5, IL-10, IL-12, IL-17A, and GRO-α (growth-related oncogene-alpha) (68).