AKT1 and acute lymphoblastic leukemia: For instance, BKM120, a pan-PI3K inhibitor, preferentially induced apoptosis in the side population (SP) of cells enriched in LSCs, with a lesser effect on non-SP cells in primary T-ALL patient samples.99 Similarly, the Akt inhibitor MK-2206 induced apoptosis in a specific subset of cells (CD34+/CD4-/CD7-), which is enriched in LSCs,97 further demonstrating the potential of targeting this pathways.