The PI3K/Akt/mTOR signaling pathway is also implicated in the self-renewal of LSCs in T-ALL.13 This pathway is negatively regulated by PTEN, a tumor suppressor gene altered in 11–27% of pediatric T-ALL cases.113 Therapeutic inhibition of this pathways has shown promise in targeting LSC-enriched populations. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.