CXCL8 levels are greater in the tumor tissue of HNSCC patients than in normal tissue, and the survival time of patients with high CXCL8 mRNA levels was shorter in TCGA data (Fig. 2D and Supplementary Fig. 2B); moreover, CXCL8 was highly correlated with the infiltration of macrophages and clinical pathological stage in TCGA data (Fig. 2E and Supplementary Fig. 2C). Here, CXCL8 is linked to head and neck squamous cell carcinoma.