To further examine whether CXCL8 signaling blockade enhances the antitumor effect of nutrient starvation therapies via modulating TAMs, mice were injected i.p. with 200 μl of liposomal clodronate on days 7 after tumor inoculation and then 100 μl every two weeks for macrophage depletion (Fig. 5O). The gene discussed is CXCL8; the disease is neoplasm.