CXCL8 and head and neck squamous cell carcinoma: In this study, we report that in HNSCC, CXCL8 expression is activated via NF-κB/p65 protein phosphorylation at the Ser536 site by ROS induced under conditions of glucose deficiency, whereas CXCL8 increases CLU expression in TAMs to facilitate antioxidative stress in cancer cells.