Furthermore, the SPI1-dependent transcriptional pathway could drive the interleukin (IL)-33-induced epigenetic and transcriptional regulation of microglial state transition, thereby enhancing beta-amyloid (A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β) clearance and alleviating AD pathology [64]. Here, SPI1 is linked to Alzheimer disease.