PSMG3 and schizophrenia: Partially because of its intricate annotation profiles, the other TWAS methods failed to detect the significance of PSMG3. Interestingly, in a recent study investigating schizophrenia from an evolutionary perspective, the SNP rs3800926, located in a human accelerated region (HAR), was validated to play function in schizophrenia, and this SNP is mapped to PSMG3 [72].