For instance, PES1 shows associations with anorexia nervosa, depression, and schizophrenia, and has strong interactions with genes like WDR74, RBM28, and RRP7A. This suggests that PES1 could be a key player in the pathogenesis of these conditions, acting as a hub that links various genetic pathways. This evidence concerns the gene WDR74 and anorexia nervosa.