AKT1 and obesity due to melanocortin 4 receptor deficiency: As a result, essential bioactive compounds are produced such as nattokinase, biogenic amines and isoflavones which are efficient inhibitors against mTORC1 which are inhibitors to autophagy via AKT pathway [35]; a mechanism to be the culprit behind the development of diabetes mellitus type 2 with obesity [9, 36].