This finding suggests that the EDF1/CaM interaction in NB cells is tightly regulated by Ca2+ level, and the dissociation of EDF1 from cytosolic CaM facilitates nuclear EDF1-mediated DNA binding with NF-κB p65/RelA, leading to the subsequent transcriptional activation of ST8SIA1. Here, NFKB1 is linked to neuroblastoma.