Conversely, Diener et al. demonstrated that SALL4 negatively regulates the invasiveness of melanoma by interacting with Histone Deacetylase 2 (HDAC2) and directly binding to genes associated with invasiveness, such as Nerve Growth Factor Receptor (NGFR), E26 Transformation-Specific 1 (ETS1), Fibronectin 1 (FN1), Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1), and Platelet-Derived Growth Factor C (PDGFC). The gene discussed is FLT1; the disease is melanoma.