Combining MAGE-A4 with other MAGE family members (e.g., MAGE-A3) or other tumor-associated antigens may lead to more effective multi-target immunotherapy strategies (Cesson et al. 2011).Furthermore, detection of MAGE-A4 expression may aid in the early detection and diagnosis of head and neck tumors. This evidence concerns the gene MAGEA4 and head and neck neoplasm.