MAGEA4 and neoplasm: In contrast, it is virtually absent in normal tissues, with only minimal expression in specialized tissues such as the testes, thus conferring high tumor specificity (Figueiredo et al. 2011).Multiple studies have demonstrated that high MAGE-A4 expression levels correlate with advanced clinical stages, increased metastatic potential (e.g., lymph node metastasis), and poorer prognosis, including shortened overall survival.