Our study revealed that OLR1, a class E scavenger receptor associated with atherosclerosis and involved in the activation of immune cells and inflammatory processes (Truthe et al. 2024; Sánchez-León et al. 2024), is a key mediator in the suppression of lipogenesis following ALA-PDT in both XL-i-20 sebocytes and an acne-like mouse model. This evidence concerns the gene OLR1 and atherosclerosis.