UCP1 and cancer: Using a luminescent cell viability assay (Methods), we observed an increased reduction in the number of cancer cells cultured with CRISPRa-UCP1-AAV adipocytes compared to 6-aminonicotinamide and a slightly increased reduction compared to etomoxir (two-tailed t-test P = 0.0163 versus P = 0.0319 for CRISPRa-UCP1-AAV or etomoxir, respectively; Extended Data Fig. 1n).