Finally, to show that this approach can be customizable for other tumor-associated metabolic programs, we show how CRISPRa upregulation of uridine phosphorylase 1 (UPP1) in adipose organoids can suppress xenograft growth of a uridine-dependent pancreatic ductal adenocarcinoma (PDA)35. Here, UPP1 is linked to Patent ductus arteriosus.