ITGB4 and cancer: Among the downregulated genes in the standard chow tumors co-implanted with UCP1-CRISPRa-modulated adipose organoids, we found many metabolic genes, including CPT1b, SCD (stearoyl-CoA desaturase) and FASN (fatty acid synthase), and cancer growth and progression regulated genes, such as MKI67, ITGB4 (ref. 51), LLGL2 (ref. 52), GATA3 (ref. 53), EEF1A2 (refs. 54,55) and TBX2 (ref. 56) (Fig. 3j).