The three oncogenes, Cytotoxic T Lymphocyte Associated Antigen 4 (CTLA-4), Programmed death-ligand 1 (PD-L1), and Programmed Cell Death Protein 1 (PD1), were primarily concerned with promoting the growth of colorectal cancer (CRC), worsening inflammatory reactions, and metastasis through the secretion or activation of cytokines and chemokines in the tumor microenvironment16–19. The gene discussed is CTLA4; the disease is colorectal cancer.